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Exploring Colorado’s leadership in psilocybin-assisted therapy and mental health research As Colorado continues to lead the nation in natural medicine reform and research, a groundbreaking clinical trial is underway to explore whether psilocybin , the active compound in magic mushrooms , can help ease the emotional suffering experienced by people living with advanced cancer. A New Frontier in Mental Health and Palliative Care The study — now the largest national psilocybin clinical trial for cancer patients  — is being conducted at the University of Colorado Anschutz Medical Campus  in collaboration with New York University . Funded by the National Cancer Institute , the trial is investigating how guided psilocybin therapy might reduce anxiety, depression, and fear of death  in patients coping with late-stage cancer. Traditional antidepressants and talk therapy often fall short for people navigating the emotional and existential weight of cancer. Psilocybin-assisted therapy offers a new approach — one that helps individuals access deeper meaning, connection, and peace through carefully guided, therapeutic psychedelic experiences. How the Trial Works Participants begin with several preparatory therapy sessions before receiving a 25-mg dose of synthetic psilocybin or a placebo. Each session takes place in a quiet, supportive environment with two trained facilitators who stay with the participant throughout the eight-hour experience. During the session, patients wear eye masks, listen to curated music, and are encouraged to explore whatever emotions or insights arise. Afterward, participants meet with the same therapists for multiple integration sessions  to help process and apply what they experienced — a vital part of the healing process. Why Psilocybin? Dr. Stacy Fischer, a palliative care specialist at UCHealth leading the Colorado arm of the study, explains that traditional treatments don’t always meet the needs of patients in emotional distress. “Antidepressant medications often have little benefit for these patients,” Fischer says. “Psilocybin may provide a faster and more profound sense of relief.” Past research from NYU and Johns Hopkins has shown that psilocybin-assisted therapy can dramatically reduce existential distress, improve quality of life, and help patients reconnect with a sense of purpose and peace — with benefits lasting for months after a single session. Colorado’s Role in Psychedelic Education and Research Colorado is quickly becoming a national hub for psychedelic therapy research and education. The University of Colorado Center for Psychedelic Research has launched the state’s first DORA-approved facilitator training program, ensuring that future psychedelic practitioners receive ethical, evidence-based instruction rooted in safety and compassion. Dr. Jim Grigsby, co-director of the center, emphasizes the importance of this approach: “When patients feel safe, supported, and respected, the healing potential of psychedelics becomes far greater.” Looking Ahead: The Future of Psychedelic Medicine in Colorado While psilocybin remains regulated under federal law, Colorado’s Natural Medicine Health Act has opened new opportunities for responsible research, training, and access. With studies like this one underway, researchers and clinicians are optimistic about the future of psilocybin-assisted care — especially for people facing life-threatening illnesses and emotional suffering. “Over time,” Dr. Fischer notes, “as we continue to conduct high-quality, rigorous science, the stigma will fade and new paths for healing will emerge.” Colorado Cultures At Colorado Cultures, we believe in the responsible study and understanding of all forms of fungi — from cultivation and genetics to their potential therapeutic value. As Colorado continues to pave the way in psilocybin research, we’re proud to support education, science, and community discussions that honor the healing potential of the mushroom kingdom.

When the cold weather rolls in, mushroom growers face a new challenge — maintaining the perfect environment for healthy, consistent fruiting. Temperature swings, low humidity, and dry indoor air can all impact your yields if you’re not ready for them. The good news? With a few simple adjustments, you can keep your grow thriving all winter long. Here’s your complete guide to winter-proofing your mushroom grow room. 1. Maintain Stable Temperatures Most mushroom species prefer a steady range between 70–80°F  during colonization and 60–70°F  during fruiting. In winter, indoor temps can fluctuate more than usual, which can slow colonization or even stall growth. Tips: Use a digital thermometer  or hygrometer  (like the ones sold at Colorado Cultures) to monitor conditions. Add a small space heater  with a built-in thermostat to maintain a consistent temperature. Avoid pointing heat directly at your grow bags or tubs. If using a grow tent, insulate the walls  with reflective mylar or foam board to retain warmth. 2. Combat Dry Winter Air Cold air holds less moisture, and indoor heating systems make it even worse — dropping humidity levels below what mushrooms love (usually 85–95% for fruiting). Tips: Run a humidifier  or misting system  to keep your fruiting chamber hydrated. Mist lightly but frequently if humidity dips below target levels. Use plastic sheeting or zippered tents  to trap humidity around your fruiting area. 3. Improve Airflow Without Losing Heat Fresh air exchange (FAE) is critical for strong, healthy mushrooms — but cold drafts can quickly drop your temperatures. Tips: Use small oscillating fans  on low settings rather than open vents or windows. Add inline fans with filters  if you need more airflow without temperature loss. Run fans on timers  to balance oxygen levels while keeping warmth stable. 4. Adjust Your Light Schedule Mushrooms don’t rely on intense light but do respond well to consistent exposure.During darker winter months, supplement with LED grow lights  or daylight-spectrum bulbs  on a 12-hour light cycle .This ensures even growth and helps your mushrooms orient properly during fruiting. 5. Keep It Clean and Contamination-Free Cold months often mean more time indoors — and more potential for contaminants to spread. Dust, mold spores, and bacteria thrive in enclosed spaces. Tips: Wipe down surfaces with isopropyl alcohol  regularly. Keep HEPA filters  or air purifiers running if possible. Store unused substrates and supplies in airtight bins. Use Denver Dirt substrate  or other high-quality sterile materials to reduce contamination risk. 6. Bonus: Optimize with Fungi Fuel Winter can slow biological processes — including mycelium growth. A boost of nutrients like Fungi Fuel  can help your culture stay vigorous even when the temperature dips. Simply add it to your substrate or grain bag to give your mushrooms an extra energy source during the colder months. Final Thoughts Winter doesn’t have to slow down your grow — it just means adapting your setup to match the season. With stable temps, high humidity, and a clean, controlled environment, you can keep producing healthy flushes all year long. If you need help optimizing your setup, stop by Colorado Cultures’ Lakewood or Englewood locations  to talk to our team, or shop online for grow bags, substrates, and cultivation tools designed to keep your mushrooms happy all winter long.

Okinawa in a CC 3lb Mixed Popcorn All in One Grow Bag If you’ve ever harvested a mushroom with perfect genetics —thick stems, heavy yield, or a stunning cap—you’ve probably wondered how to grow more just like it. Cloning makes that possible. Instead of rolling the dice with spores, cloning lets you preserve and replicate the exact traits of your best-performing mushroom. In this step-by-step guide, we’ll show you how to clone mushrooms using supplies you can grab from Colorado Cultures. Why Clone Mushrooms Instead of Using Spores? Spores = genetic lottery | Clones = genetic copy Here’s why cloning is a favorite among serious growers: Consistent yields Predictable potency and appearance Faster colonization times No risk of mutation or weak genetics You preserve your best traits Spores are great for variety—clones are ideal for performance. Step 1: Gather Your Supplies You don’t need a lab—just the right sterile tools. We recommend: From Colorado Cultures: Still Air Box or Flow Hood Scalpels or Exacto Knife (sterile) Alcohol wipes / 99% isopropyl alcohol Sterilized grain jars or All-in-One grow bags Liquid Culture jar Petri dishes with agar Extras: Gloves Paper towels Isopropyl Alcohol Step 2: Select the Perfect Mushroom CC 3rd Eye in a CC 3lb Mixed Popcorn All in One Grow Bag Choose a mushroom with the traits you want to preserve: Dense/thick stems Strong canopy formation High yield genetics Fast growth Vibrant cap color No contamination Avoid mushrooms that are: Mutated unintentionally Overly mature Soft or waterlogged Shriveled or damaged Step 3: Prepare Your Workspace Sanitation is EVERYTHING when cloning. Spray down your still-air box or work area with 99% isopropyl alcohol. Wipe tools and surfaces. Wear gloves and sanitize your hands. Have everything laid out before you begin. If you’re using a flow hood, let it run for at least 15 minutes before starting. Step 4: Make a Clean Tissue Sample Tear (not cut) the mushroom in half vertically to expose the sterile inner tissue. Sterilize your scalpel with 99% isopropyl alcohol. Remove a rice grain-sized piece from the center of the stem. This internal tissue is your cleanest starting point. Step 5: Transfer to Agar or Grain Option 1: Clone to Agar (Best for Clean Expansion) Place the tissue sample in the center of a sterile agar dish. Seal the plate with parafilm. Store between 68°F–75°F. Watch for white, ropey mycelium growth over the next few days. Option 2: Clone Directly to Grain Open your sterilized grain bag inside your sterile workspace. Drop the tissue inside quickly. Close immediately and shake lightly. Not as clean as agar, but faster for beginners. Step 6: Expand and Inoculate Once the clone has colonized: If using agar: Cut clean wedges and transfer to new agar, LC, or grain. If using grain: Use the colonized jar/bag to inoculate bulk substrate like Denver Dirt  or all-in-one bags . Step 7: Watch for Contamination Look out for: Grey (cobweb mold) Green patches (trich) Excessive Yellow/brown liquids (bacteria) Odd smells Healthy mycelium is: White Ropey or fluffy Evenly spreading If you’re unsure, you can send us a photo or stop by the shop for help. Pro Tips for Better Clones Clone mushrooms that are young but fully formed Avoid fruiting bodies exposed to high humidity damage Always sterilize between transfers Use agar if you want the cleanest results Keep backup clones in the fridge or slants for long-term storage Need Supplies? We’ve Got You Covered Colorado Cultures carries everything you need for cloning success: Still Air Boxes, Sterilized Grain Jars & Bags, Flow Hoods, Agar & Petri Dishes, Alcohol & Sterile Tools, Liquid Culture Jars, Denver Dirt, etc. Stop by our either of our locations or order online and have high quality mycology supplies shipped right to your door.

Penis Envy The world of psilocybin mushrooms is full of hundreds unique genetics, but few strains have sparked as much curiosity, debate, and legend as Penis Envy . Known for its thick stems, bulbous caps, and exceptionally high potency, Penis Envy isn’t just visually distinct—it carries one of the most interesting origin stories in modern mycology. Origins: The Terrence McKenna Connection Terrance McKenna in the Amazon The most widely accepted origin story begins in the 1970s  with ethnobotanist and psychedelic pioneer Terence McKenna . During travels in the Amazon, McKenna reportedly collected wild Psilocybe cubensis  spores. These spores eventually made their way into the hands of other mycologists and underground cultivators in the U.S. Sometime after, a unique mutation emerged from these genetics—one with: Thick, inflated stems Undersized or undeveloped caps Reduced spore production Slow colonization but extreme potency Its distinct shape and “chubby” appearance led to the nickname Penis Envy , which stuck. The Role of Steven Pollock Dr. Stephen Pollock News Article About Death Another important figure in its development was Dr. Steven Pollock , a physician and mycologist from Texas. Pollock was known for experimenting with psilocybin genetics, and many believe he further isolated and stabilized the Penis Envy mutation. While the true chain of custody is debated, his contributions helped make the strain accessible to underground growers in the late ’70s and early ’80s. Why Penis Envy Became Legendary Several features make this mushroom stand out: ✅ Unmatched Potency Penis Envy strains typically contain 50–100% more psilocybin and psilocin  than most other Psilocybe cubensis  varieties. That’s why many experienced users dose it at half or even one-third  the amount they would for a standard cube. ✅ Unique Growth Characteristics Unlike typical cube strains, Penis Envy mushrooms: Are slow colonizers Produce dense, meaty fruits Drop very few spores Often require cloning or liquid culture to propagate Because of low spore output, Penis Envy wasn’t easy to spread, which added to its mystique. ✅ Cultivation Challenges For decades, only skilled cultivators could reliably grow it. The lack of spores made prints and syringes rare, and most early propagation was done through tissue culture. Even today, many growers use isolations, all-in-one bags, or grain-to-grain transfers  rather than spores. Modern Variants and Hybrids Tidal Wave x APE As the genetics became more accessible, new Penis Envy crosses and mutations were born, including: Albino Penis Envy (APE) Penis Envy Uncut Tidal Wave (Penis Envy x B+) Melmac (Alleged original PE mutation) Wormhole (APE x Chodewave) PE x Jedi Mind Fuck, PE x Golden Teacher, PE Supreme  and more These hybrids preserve much of the potency and physical bulk while improving sporulation or yield. Cultural Impact Today, Penis Envy is one of the most sought-after psilocybin genetics worldwide. It's known for: Visual distortion and introspection Strong body waves Profound emotional breakthroughs Spiritual experiences and ego dissolution Its name may be playful, but its effects and history are taken seriously by cultivators, psychonauts, and researchers alike. The Legacy Lives On From its mysterious birth in the Amazon to its modern-day status as a powerhouse genetic, Penis Envy remains one of the most influential mushrooms in cultivation culture. Its look, potency, and legend have inspired dozens of modern hybrids and continue to shape the future of mushroom breeding. If you’re exploring the world of premium psilocybin genetics—or offering them through your brand—Penis Envy is the blueprint that helped define potency, mutation, and mystique in modern mycology.

If you’re new to mycology, you’ve probably come across the term field capacity . It’s one of the most important concepts for successful grows, but it often gets overlooked by beginners. In this guide, we’ll break down what field capacity means, why it’s critical for mushroom health, and how you can test it in just a few seconds. What Is Field Capacity? Field capacity refers to the ideal moisture content in your substrate —wet enough to support strong mycelial growth, but not so wet that it drowns the fungi or promotes contamination. Think of it like the “sweet spot” between soggy and bone-dry. At field capacity, your substrate should feel hydrated and fluffy without pooling water. Why Does It Matter? Healthy Mycelium Growth  – Mycelium spreads fastest in properly hydrated substrate. Prevents Contamination  – Too much water can create anaerobic conditions (lack of oxygen), which invite bacteria and mold. Better Yields  – Balanced moisture supports consistent fruiting and larger flushes. How to Test Field Capacity The most common way is the squeeze test : Take a handful of prepared substrate. Squeeze it firmly in your fist. If a few drops  of water come out, it’s at field capacity. ✅ If water pours out , it’s too wet. ❌ If nothing comes out  and it feels crumbly, it’s too dry. ❌ Adjust as needed: Too wet? Add more dry substrate and mix well. Too dry? Mist in small amounts of clean water until it balances. Tips for Beginners Always test after mixing, not before. Moisture distributes unevenly until mixed thoroughly. Use clean, filtered water  where possible. Tap water is fine for most grows, but avoid heavily chlorinated water. Don’t obsess over perfection—the squeeze test is more than enough for hobby-level grows. Conclusion Mastering field capacity is one of the easiest ways to boost your success as a mushroom grower. Once you know what the “right moisture” feels like, it becomes second nature. With practice, you’ll be able to tell at a glance whether your substrate is ready for colonization.

Most people know the classics — Golden Teacher, B+, Blue Meanies, etc. But at Colorado Cultures, we love going beyond the basics. Our shelves feature rare and exotic genetics  from all over the world, giving growers access to unique genetics that expand skills, yield new looks, and spark curiosity. Here’s a deep dive into four of some intriguing genetics we’re currently working with. Why Rare Genetics Matter Rare and exotic mushroom genetics are more than just eye-catching. They bring: Unique Growth Traits  – each genetic line has its own environmental preferences. Visually Striking Fruiting Bodies  – everything from coral-like blobs to vivid ochre caps. Learning Opportunities  – unusual genetics push you to become a more versatile cultivator. Our Featured Rare & Exotic Genetics MIB Pan Cyan (Panaeolus cyanescens) This “Men in Black” hybrid combines several Panaeolus cyanescens  genetics — PHV, BVI, and Nec’D — into one powerful package. Known for its small yet elegant fruits, intense blue bruising, and black spore print, MIB Pan Cyan is a favorite among experienced growers seeking something beyond Psilocybe cubensis . Preferred Substrate : Dung or manure-based Temperature : 75–85 °F (25–30 °C) Humidity : 90–100% during fruiting Why Grow It : Significantly more potent than typical cubes and a chance to master a more demanding genetic line Enigma (Tidal Wave x PE Mutation) Enigma is not your typical mushroom. This rare Psilocybe cubensis  genetic mutation forms dense, coral-like masses of mycelium and fruiting tissue instead of traditional caps and stems. Because it doesn’t reliably produce spores, growers propagate Enigma from tissue cultures or clones. Appearance : Brain-like clusters rather than classic mushrooms Temperature : ~70–75 °F (21–24 °C) Humidity : 85–90% Why Grow It : One of the most visually striking and conversation-worthy genetics; a great challenge for mycologist ready to experiment Belafonte (True Albino Teacher Mutation) Belafonte is an exotic cube mutation gaining traction in the mycology community. Known for its vibrant blue and silver coloration and robust yields, it offers something different from mainstream varieties without an extreme learning curve. Preferred Substrate : Standard cube substrates (manure or compost-based) Cultivation : Similar to classic Psilocybe cubensis , but monitor cap development closely Why Grow It : A unique cube with impressive yields and aesthetics, perfect for expanding your genetics library P. Ochra (Psilocybe ochraceocentrata) Formerly confused with Psilocybe natalensis , this newly clarified genetic line is the closest known wild relative of Psilocybe cubensis . Native to Southern Africa, it’s prized for its aggressive growth and striking ochre-toned caps. Preferred Substrate : Dung-enriched soils or compost Temperature : 74–80 °F (23–27 °C) Humidity : 85–95% Why Grow It : Newly recognized genetics, aggressive colonizer, and a must-have for anyone passionate about exotic mushroom genetics Tips for Success with Rare Genetics Start Small : Test each genetic line before scaling up. Dial in Conditions : Exotic genetics can demand tighter control of humidity and temperature. Use Premium Substrates : Rare genetics deserve the best — try Denver Dirt  or Fungi Fuel  to maximize performance. Document Your Grows : Track conditions and outcomes so you can refine your technique. Why Buy from Colorado Cultures We’re not just a supplier — we’re a hub for education and support. Every genetic line in our catalog is carefully sourced and tested. When you order from Colorado Cultures, you also gain access to our team’s knowledge and guidance to help your grow succeed. Final Thoughts Exploring rare and exotic mushroom genetics is one of the most rewarding aspects of mycology. Whether you’re building your genetics library, challenging yourself as a mycologist, or simply fascinated by unique forms and colors, these genetics deliver. Check out our latest genetics and substrate options at Colorado Cultures  and discover genetics you’ve never heard of — until now.

When growing mushrooms, many beginners focus on substrate, sterilization, and spawn—but two environmental factors often make or break your crop: humidity  and airflow / fresh air exchange (FAE) . The right balance of these isn’t just “nice to have” — it’s essential for healthy growth, good yields, and avoiding contamination. Below, we’ll dig into what role each plays, what the risks are when things are off, and how to dial them in for different phases of cultivation. The Role of Humidity What it is:  Relative Humidity (RH) refers to how much moisture the air can hold relative to its maximum at a given temperature. Mushrooms are composed of ~80-90% water, so their tissues depend heavily on the moisture content of the air around them. Why it matters: Pinning and Primordia Formation: Mushrooms begin life as tiny bumps called primordia or pins. High humidity helps initiate and sustain this stage by preventing drying out of the substrate surface and forming conditions where pins can develop properly. Low humidity here will stall or abort pin formation. Fruit Body Development: Once the pins are set, the mushrooms need consistent moisture so that flesh grows full, caps expand, and stipes (stems) don’t crack. Dry air leads to deformation, cracked caps, stunted growth, or even aborts. Avoiding Issues from Too-Much or Too-Little Too low humidity causes drying, unusable fruit, lower weight, more fragile mushrooms. Too high humidity, especially without enough airflow, encourages condensation, pooling of water, and breeding grounds for bacteria, molds, and other contaminants. Typical RH Ranges: During incubation / colonization  (when mycelium is colonizing substrate), moderate humidity is okay, often ~70-80%. Too high here might encourage unwanted mould. During pinning  and fruiting , higher targets: 85-95% RH is often ideal. Some growers aim near 95-100% RH for pinning. The Role of Airflow / Fresh Air Exchange Humidity is only one half of the equation. Without good airflow and periodic fresh air exchange (FAE), high humidity becomes a liability. What airflow does: Reduces CO₂ Buildup: Mushrooms release carbon dioxide (CO₂) during respiration. If CO₂ accumulates, it can lead to long, thin stems, delayed development of caps, and generally poor morphology. Fresh air brings oxygen and helps trigger fruiting. Prevents Stagnant, Unhealthy Air: Stagnant air favors contaminant growth – molds, bacteria, etc. Moving air helps reduce pockets of dampness, reduces condensate, and keeps surfaces drier while still supporting moisture. Helps Humidity Control / Balance: Proper airflow allows growers to manage humidity more precisely. For example, if RH creeps up too high (condensation forming), you can increase FAE or use stronger ventilation. If RH drops, you can reduce ventilation or add misting/humidifiers. This interplay is especially important during fruiting. Balancing Humidity + Airflow: The Sweet Spot Because humidity and airflow pull in opposite directions (humidity wants still, moist air; airflow tends to dry things out), the grower’s job is finding a balance, which shifts by phase. Here are some practical tips: Phase Humidity Target Airflow / FAE Needs Things to Watch Out For Incubation / Colonization ~70-80% RH Minimal airflow; keep side holes closed or low ventilation; avoid drafts Too much air dries substrate; too little allows CO₂ to build if bags are sealed poorly; risk of bacterial growth if condensation/saturation increases inside the container. Pinning Trigger Raise RH toward 90-95%; sometimes near saturation to form condensation on surfaces Introduce bursts of fresh air / intermittent FAE to trigger pin formation; this often involves opening vents, fanning, etc. If airflow or RH shifts too abruptly you might dry the substrate, stall pins, or shock the mycelium. Also ensure that water doesn’t pool. Fruiting & Harvest Maintain ~85-95% (species dependent) More FAE, but careful so as not to drop RH too low; frequent air exchange helps avoid off-odors and contamination and keeps CO₂ down. Fans or vents should be clean and sometimes filtered. Watch for drying caps / stems; watch for mold or bacterial blotches if RH stays high too long with low airflow; maintain sanitation. Practical Tools & Adjustments To effectively control both humidity and airflow, you’ll want some reliable tools & setup adjustments: Hygrometers / Humidity Sensors  — ideally digital, with good accuracy, placed at substrate surface height. Monitor consistency. Humidifiers / Mist Makers  — ultrasonic humidifiers or fine mist systems help maintain high humidity without drenching things. Be careful of over-spraying. Ventilation / Fans  — low-speed fans, periodic or clipped to controllers/timers, fresh air inlets, exhausts, or passive holes (with filters if possible) to allow FAE. Controller Systems  — automated humidistat / RH controllers, timers for fans, CO₂ sensors if you want advanced tuning. Proper Sealing & Material  — fruiting chambers, bags, tubs need to retain moisture well but allow for some gas exchange. Use perlite, plastic, or other humidity-retaining materials where needed. Common Problems When Things Go Wrong Dry caps / cracked mushrooms  — usually due to insufficient humidity or overly aggressive airflow. Aborted or no pins  — can be caused by high CO₂ or low humidity during pinning stage. Mold, bacteria, slimy patches  — often from too much moisture without enough airflow, or condensation / water pooling. Uneven growth or yield loss  — parts of a fruiting chamber or tub may be drier or more stagnant than others if airflow is poorly distributed. Species & Strain Differences Not all mushrooms have exactly the same needs. Some are more tolerant of lower RH, others require almost saturated humidity. For example: Hericium erinaceus  (Lion’s Mane) likes RH around 85-90% . Some tougher mushrooms (Reishi, Turkey Tail) can handle slightly lower humidity; delicate ones (Lion’s Mane, Enoki) need very high and stable humidity. So it’s always good when selling or advising on strains to include: “What humidity range does this strain prefer?” Final Thoughts Humidity and airflow are among the foundational environmental controls in mushroom cultivation. Getting them right makes much of the rest easier—lower contamination, better yields, more consistent results, and healthier mushrooms. When you set up your grow space (even small or DIY), think of how you’ll maintain high RH during fruiting and  how you’ll ensure enough fresh air and gas exchange without drying things out or introducing contaminants.

Colorado’s natural medicine law came out of Proposition 122 (2022) . It created a regulated framework for certain plant‐, fungi‐, or mushroom‐based therapies (e.g. psilocybin), defining what’s allowed, who can provide services, and how. A number of license types are now required under the law. DPO Colorado+2Psychedelic Alpha+2 The Main Licenses & Credentials Here are the major kinds of licenses / registrations you’ll encounter under Colorado’s natural medicine regulations, and what each one involves: License / Role What It Allows You to Do Requirements / Qualifications Facilitator A “Facilitator” provides natural medicine services such as preparation sessions, administration sessions, and integration sessions. They are non-clinical providers under the Natural Medicine rules. Colorado Secretary of State+2Vicente LLP+2 Must be ≥ 21 years old; basic life support (or equivalent) certification; complete an approved facilitator training program; do a supervised practicum (≈ 40 hours); do consultation hours (≈ 50 hours) with an approved mentor or supervisor. Application, fees, and background checks are required. Colorado Secretary of State+2Psychedelic Alpha+2 Clinical Facilitator A Clinical Facilitator has a broader or more medical/clinical scope; the rules indicate more rigorous training or existing license in a health profession, possibly able to work with higher risk patients. Vicente LLP+2Colorado Secretary of State+2 Same base adult age, BLS, etc. + must hold or be licensed in a relevant health profession (e.g. certain medical credentials) or additional training. More restrictions / oversight. Colorado Secretary of State+1 Handler License For individuals who “handle” regulated natural medicine or regulated natural medicine products—this includes people involved in cultivation, manufacturing, testing, packaging, storage, or transport. Everyone who has unrestricted access or handles the product in business settings needs a Handler License. Colorado Secretary of State+2Colorado Secretary of State+2 Must be 21; pass a criminal history background check; pay fees; meet any requirements around identifying who handles what. Some licensees (owners, facility staff) will also need to hold a natural medicine handler license. Colorado Secretary of State Owner License If you own (or have financial interest in) a natural medicine business (healing center, cultivation facility, manufacturing, testing facility), you’ll need an Owner License. This allows you many of the same privileges as a handler, because owners must also handle regulated natural medicine in many cases. Colorado Secretary of State+1 Similar base requirements: ≥ 21, background check, tax / financial disclosures (since ownership implies financial liability), fees, etc. Colorado Secretary of State Natural Medicine Business Licenses  (Healing Center, Cultivation Facility, Manufacturer, Testing Facility) These are for entities (business premises) that operate cultivation, manufacturing, testing, healing centers, etc. They must be licensed by the state. Heal­ing centers are where participants go to receive natural medicine services under supervision. Cultivation/manufacturing and testing have operational / facility / inventory / safety / labeling / tracking requirements. Colorado Secretary of State+3dnm.colorado.gov+3Psychedelic Alpha+3 Must meet facility standards; owners must have owner licenses; handler licenses for employees; security, inventory tracking, safety, testing; may be categorized by “tiers” (like micro vs standard) depending on scale (e.g. how much dried fruiting bodies can be stored) Colorado Secretary of State+2dnm.colorado.gov+2 Some Key Shared Requirements Across almost all of the license types, there are a number of common requirements: Must be 21+ years old . Colorado Secretary of State+1 Basic Life Support (BLS) or equivalent certification. Colorado Secretary of State+1 Criminal history / background check. Colorado Secretary of State+1 Application, fees, and compliance with the rules about handling, storage, labeling, safety, record-keeping. Colorado Secretary of State+2Colorado Secretary of State+2 “Tiers”, Business Types & Other Factors Tiers : Some licenses (especially cultivation facilities) have tiers (e.g. micro-cultivation vs standard) depending on the scale (how much medicine they handle/store). The scale affects how much inventory in dried fruiting bodies you are allowed, what security / location / storage / record keeping is needed. Colorado Secretary of State+1 Business vs Individual : License categories include both individual licenses (facilitators, handlers, owners) and business entity licenses (healing centers, manufacturing, cultivation, testing). Colorado Secretary of State+1 Local vs State : In addition to state licenses, many municipalities require local business licenses or permits (e.g. Denver, Boulder, Sheridan) for natural medicine businesses. Zoning, distance from schools, business permits, local ordinances will matter. Denvergov+1 Timeline & Recent Changes The Natural Medicine Advisory Board was appointed in 2023. DPO Colorado Licensing for facilitators opens in December 2024. DPO Colorado Rules went into effect October 1, 2024. dnm.colorado.gov +1 What To Know Before You Apply If you’re considering getting licensed under Colorado’s natural medicine law, here are a few things to check: What role are you seeking?  Facilitator? Clinical facilitator? Owner? Handler? Business entity? Each has different training and legal obligations. Do you meet the prerequisites?  Age, certification (BLS), background, may need to hold other licenses or have clinical credentials for certain roles. Training program : Find an approved facilitator training program (for Facilitators/Clinical Facilitators). You’ll need to complete supervised practicum, consultation hours. Facility & business setup  (if doing business): Comply with facility licensing rules, security, inventory, local zoning, permits. Ongoing compliance : Renewal of license, maintaining training, keeping records, safety screening, reporting, etc. Other Related Licenses Besides the new natural medicine licenses, Colorado also regulates or registers other “natural” or complementary health practitioners, such as: Naturopathic Doctors (NDs)  – they earn a doctorate from accredited naturopathic medical programs, are registered/licensed in Colorado, must pass board exams, and fulfill continuing education requirements. coloradond.org Herbalists, wellness coaches, etc. These may not yet have specific state licenses (unless under the Natural Medicine rules or other health board rules), so their regulation may vary and might not be formal licensing but could involve business permits, scope limitations, ethics, etc.

Denver, August 27, 2025  — Yesterday, Denver hosted an important Natural Medicine Listening Session , bringing together the Department of Revenue’s Natural Medicine Division (NMD) , the Department of Public Health & Environment (CDPHE) , the Department of Regulatory Agencies (DORA) , and the Governor’s Office . This collaborative discussion focused on how Colorado is moving forward with its groundbreaking Natural Medicine laws , especially around the regulated use of psilocybin mushrooms . For the mycology community and those interested in the future of psychedelics, this session represented a major step in making Colorado the nation’s—and possibly the world’s—leader in safe, legal natural medicine access . Why the Listening Session Matters Colorado voters made history by legalizing regulated access to natural medicines like psilocybin , but creating a safe and effective framework requires more than passing laws. Yesterday’s listening session showed that state leaders are working hard to: Ensure compliance with Colorado mushroom laws  so individuals, facilitators, and healing centers all remain within legal limits. Clarify licensing requirements  for psilocybin facilitators, healing centers, cultivation facilities, and testing labs. Support community education  by providing clear guidance on what is permitted under Colorado’s natural medicine framework. Collect valuable feedback  from Coloradans on what challenges exist and how agencies can better support participants in this new industry. For those of us in the mycology supply  world, this session confirmed that education, safety, and compliance are top priorities moving forward. Colorado’s Global Data Leadership One of the most exciting outcomes from the session is Colorado’s commitment to collecting the world’s largest set of data on natural medicine use . By tracking outcomes across licensed healing centers and facilitators, the state hopes to generate valuable insights on: Mental health outcomes for conditions like depression, anxiety, and PTSD Safety and risk management in community settings Best practices for facilitators and psilocybin healing centers Real-world accessibility and use patterns across Colorado communities This data-driven approach could make Colorado the global leader in natural medicine research , setting a standard for other states—and even other countries—looking to responsibly regulate natural medicines. Milestones Already Reached Colorado’s progress on natural medicine isn’t just theoretical—it’s already happening: The first legal psilocybin therapy session in the U.S.  took place this summer at a licensed healing center in Colorado. Facilitator, cultivation, and healing center licenses  are being granted, with more approvals expected over the next year. Agencies are hosting listening sessions in Denver and across the state  to ensure that the public remains part of the process. This progress shows that Colorado is more than just a pioneer—it’s building a sustainable, community-driven natural medicine model . What This Means for Colorado Cultures At Colorado Cultures , we are proud to be part of this historic moment. As a mycology supply store in Denver , we support growers, hobbyists, and educators who are passionate about mushrooms and their role in the natural medicine movement. Here’s how we see our role in this evolving landscape: Compliance support : Helping our community understand Colorado mushroom laws  and how to stay within legal limits. Education and resources : Offering workshops, blog updates, and hands-on knowledge to empower safe and responsible mycology practices. Community connection : Our stores are more than shops—they’re hubs for conversation, education, and collaboration around mushroom cultivation and natural medicine. Supporting research and data : By promoting responsible cultivation and sharing best practices, we contribute to the overall data that will shape the future of psilocybin Colorado programs . Why Colorado Is Setting the Standard Other states like Oregon may have pioneered early models for psilocybin regulation, but Colorado is setting itself apart with a data-first, community-driven approach . By prioritizing public feedback, robust oversight, and measurable outcomes, Colorado is well on its way to becoming the number one state in the world for natural medicine innovation . This leadership doesn’t just benefit policymakers—it benefits communities, facilitators, patients, and businesses like ours that support the safe and legal mushroom supply chain . Looking Ahead The rollout of Colorado’s natural medicine laws will continue over the next year, with more opportunities for community involvement, more licenses issued, and more healing centers opening their doors. At Colorado Cultures , we’ll continue to follow these developments closely and share updates through our blog, social media, and in-store events. Our goal is to keep our community informed and empowered as Colorado takes its place at the forefront of natural medicine and psilocybin research . Final Thoughts This week’s listening session showed that the future of natural medicine in Colorado is bright, collaborative, and built on solid data. For anyone passionate about mushrooms, wellness, or mycology, this is an exciting time to be part of history. Visit Colorado Cultures  in Wheat Ridge or Englewood for your mycology supplies , cultivation resources, and up-to-date insights on how natural medicine laws are shaping our state’s future.

Every year, tens of thousands of people gather in the Nevada desert to create something extraordinary: Burning Man. It’s a place where art, music, and community collide in the most extreme of environments. Between the dust, the heat, and the endless energy it takes to fully immerse yourself in the Playa, one thing becomes clear—taking care of your body is just as important as feeding your creativity. That’s where mushrooms come in. Mushrooms have been used for centuries as powerful allies for energy, focus, recovery, and overall wellness. Today, functional mushroom extracts and powders make it easier than ever to bring these ancient superfoods into your festival journey. Whether you’re dancing all night, building art installations, or simply soaking in the experience, mushrooms can help keep you fueled and balanced. Lion’s Mane: Focus in the Chaos Known as the “brain mushroom,” Lion’s Mane is prized for its ability to support memory, mental clarity, and focus. On the Playa, where there’s no shortage of distractions, Lion’s Mane can help you stay present and sharpen your creative flow. Best for:  Artists, builders, DJs, and anyone looking to tap into their mental edge. Cordyceps: Natural Energy, No Crash Forget the energy drinks—Cordyceps is nature’s performance booster. Traditionally used by mountain climbers and athletes, Cordyceps supports stamina, oxygen uptake, and endurance. In the desert, that means more energy for exploring art cars, dancing under the stars, and pushing through those long, dusty days. Best for:  Movers, shakers, and anyone who plans on staying active from sunrise to sunrise. Reishi: Chill Out and Recover Called the “Mushroom of Immortality,” Reishi has long been used as a calming adaptogen that helps regulate stress and support restful sleep. After a full day of radical self-expression, your body and mind need recovery time—Reishi helps you wind down and recharge. Best for:  Night owls who need deeper sleep, or anyone looking to keep their immune system strong in the harsh desert environment. Turkey Tail: Immune Support on the Playa With thousands of people packed together in dusty, unpredictable conditions, immune health is everything. Turkey Tail mushrooms are rich in prebiotics and antioxidants that support a resilient immune system, helping you stay strong all week long. Best for:  Everyone—because staying healthy means you don’t miss a moment of the magic. Bringing Mushrooms to the Desert Our Colorado Cultures Superfood Mushroom Extract Powders and Tinctures  are lightweight, easy to use, and perfect for travel. Just mix them into your water bottle, morning coffee, or even a smoothie at camp. They’re the perfect Burner-friendly way to fuel your journey while staying connected to nature. This year at Burning Man, take a little extra care of your mind and body. Mushrooms have always been teachers, healers, and sources of inspiration—just like the Playa itself. Pack them in your bag, share them with your camp, and let them fuel the adventure.

When most people think of Colorado’s wild landscapes, they picture towering mountains, alpine lakes, and endless forests of aspen and pine. But hidden beneath the soil, tucked into decaying logs, and scattered across the forest floor is a network of organisms that quietly keeps the entire ecosystem alive and thriving: mushrooms. Nature’s Decomposers Mushrooms are the fruiting bodies of fungi, and their primary role in Colorado’s wilderness is decomposition. When trees fall, leaves drop, and plants die, mushrooms break down this organic matter into nutrients that return to the soil. Without fungi, Colorado’s forests would be choked with debris and starved of the nutrients needed to grow. Mycorrhizal Partnerships Many Colorado mushrooms, like chanterelles and boletes, form symbiotic relationships with trees . Their underground mycelium networks attach to tree roots, trading nutrients and water for sugars produced through photosynthesis. In the Rocky Mountains, this partnership helps evergreens survive the thin, rocky soils found at high altitudes. Soil Builders and Water Managers Mushrooms improve soil structure by binding particles together and creating natural pathways for air and water. Mycelium acts like a sponge, holding onto moisture and slowly releasing it back into the soil — an essential function in Colorado’s dry climate. Food for Wildlife Mushrooms aren’t just critical for soil and trees; they also provide food for Colorado’s wildlife. From squirrels stashing mushrooms for winter to elk nibbling on them during the summer, fungi are a quiet but essential part of the food web. Indicators of Ecosystem Health The presence of diverse mushroom species is often a sign of a healthy ecosystem. Conversely, the loss of fungal diversity can indicate declining soil health, pollution, or environmental imbalance. For Colorado, keeping our fungal populations strong is just as important as protecting rivers and forests. Final Thoughts The next time you’re hiking in Colorado and spot a mushroom along the trail, take a moment to appreciate its role in the bigger picture. These hidden workers recycle nutrients, sustain forests, and maintain the balance of life in our state’s wild places. At Colorado Cultures , we’re constantly inspired by the natural role fungi play in ecosystems — and we’re here to help you explore that magic through cultivation, education, and community.

At Colorado Cultures , we believe fungi are more than just a passion or a product—they’re the future. Whether you’re just starting out with your first grow kit or you’re deep into agar work and genetics, understanding why  we grow mushrooms is just as important as knowing how . The world of mycology offers so much more than just fascinating fruiting bodies—it offers solutions. From soil regeneration to mental health support, fungi are showing up as humble heroes in some of the biggest challenges we face today. Let’s dig into why mycology matters—and why we’re all in on building a culture around it. 1. Fungi Help Heal the Planet Mycelium, the underground network of fungi, plays a vital role in nearly every terrestrial ecosystem. It helps decompose organic material, cycle nutrients, and even clean up toxic waste through a process called mycoremediation . That means mushrooms and their mycelial networks: Break down pollutants like oil spills and pesticides Restore damaged or depleted soil Support healthy forests by transferring nutrients between plants These functions make fungi essential allies in the fight against climate change and environmental degradation. Pro Tip for Growers:  Even your spent mushroom blocks can be composted or used in gardens to enhance soil quality—nothing goes to waste! 2. Mushrooms Are a Sustainable Food Source As the global population grows and food systems are stressed, mushrooms offer a low-impact, high-nutrient solution . They require far less water and space than traditional livestock farming They can be grown on agricultural waste or byproducts They're rich in protein, fiber, vitamins, and antioxidants At Colorado Cultures, our Gourmet House Cultures  and Masters Mix substrate  make it easy for anyone to grow their own food at home—whether it’s gourmet oyster mushrooms, lion’s mane, or more exotic species. 3. Fungi Support Mental and Physical Wellness We’re living in a time when people are searching for more holistic, accessible approaches to mental health and wellness. Fungi are rising to the occasion. Medicinal mushrooms  like reishi, chaga, and lion’s mane are celebrated for immune-boosting and neuroprotective properties Psilocybin-containing mushrooms —the kind often grown with our Full Flush Kits —are showing incredible promise in clinical trials for depression, PTSD, addiction, and end-of-life anxiety While psilocybin remains regulated, its potential has ignited a wave of decriminalization and education across the U.S., including right here in Colorado. We're proud to be part of a movement that values plant-based healing, personal exploration, and informed access . 4. Mycology Builds Connection and Community Growing mushrooms isn’t just a solo act—it’s a doorway into a broader network of people who care about sustainability, self-sufficiency, and shared learning. Our team at Colorado Cultures has watched Myco Jam  become more than an event—it’s a celebration of culture, creativity, and the power of fungi to bring people together. Whether you’re swapping genetics, getting hands-on with agar, or just starting out with a grow kit, you’re part of something bigger. 5. Cultivating Fungi is Empowering When you grow mushrooms, you: Learn patience and observation Build your own food or medicine source Take control of your mental and physical wellness Participate in a regenerative practice For many, growing mushrooms is deeply therapeutic—and empowering in a world that often feels disconnected and overwhelming. At Colorado Cultures, our goal is to make the process easy, accessible, and successful , whether you're in a studio apartment or setting up a full grow room. Final Thoughts Mycology matters because fungi matter. They connect ecosystems, support our bodies and minds, and offer sustainable solutions that can truly change the world. We’re proud to be part of a growing movement of curious, passionate people who believe in the power of mushrooms. Whether you’re a beginner with your first H2Shroom kit , or an experienced cultivator dialing in your own genetics, you're helping build a culture rooted in growth, care, and connection. Ready to grow something that matters? Explore our full collection of kits and supplies →